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Fig. 2.   Predicted domain structures of the CLD protein and distribution of mutations. Three alternative models with 10 (A), 12 (B), or 14 (C) transmembrane segments are shown. Locations of known mutations are indicated with symbols: circles, point mutations; triangles, insertions; inverted triangles, deletions. Missense mutations are indicated with open symbols, nonsense mutations with solid symbols, and splice site mutations with striped symbols.