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Am J Physiol Gastrointest Liver Physiol 236: G550-G555, 1979;
0193-1857/79 $5.00
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AJP: Gastrointestinal and Liver Physiology, Vol 236, Issue 5, G550-G555
Copyright © 1979 by American Physiological Society

ARTICLES

Effects of colchicine and vinblastine on in vitro gastric secretion

DK Kasbekar and GS Gordon

The effects of colchicine and vinblastine on in vitro bullfrog gastric mucosal preparations were studied with respect to H+ and pepsinogen secretion. In the concentration range of 1--50 mM, an initial but transient colchicine-mediated stimulation of H+ secretion is followed by a dose-dependent inhibition. The transient stimulation of H+ secretion can be confirmed in resting preparations in the absence of added secretagogues. In the same concentration range, colchicine inhibits pepsinogen secretion to a greater degree than H+ secretion. Vinblastine (10(-5)--5 X 10(-4) M) was more effective than colchicine in inhibiting both H+ and pepsinogen secretion. The kinetics of inhibition of secretion by both colchicine and vinblastine were slow. Cytochalasin B had no effect on either secretion.




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