AJP - Gastrointestinal and Liver Physiology, Vol 238, Issue 2 131-G134, Copyright © 1980 by American Physiological Society
Intravenous indomethacin and aspirin reduce basal gastric mucosal blood flow in dogs
G. L. Kauffman Jr, D. Aures and M. I. Grossman
The effect of two known inhibitors of prostaglandin synthesis, indomethacin
and aspirin, on blood flow was studied in six Heidenhain pouch and three
antral pouch dogs. The unstimulated gastric mucosa was bathed with 0.15 M
HCl and clearance of [14C]-aminopyrine was used as an index of changes in
mucosal blood flow. [14C]aminopyrine clearance was measured during three
15-min predrug periods and five 15 min-postdrug periods. Either
indomethacin (10 mg . kg-1), aspirin (100 mg . kg-1), or 0.15 M NaCl were
given intravenously as a bolus. Indomethacin reduced mucosal blood flow in
the Heidenhain pouch 52% (P less than 0.05) and in the antral pouch 52% (P
less than 0.05). Aspirin reduced Heidenhain pouch mucosal blood flow 31% (P
less than 0.05). Indomethacin caused no significant change in electrical
potential difference or in net flux of H+ or Na+ in Heidenhain pouches.
Indomethacin (10 mg . kg-1 iv) produced no change in mean arterial
pressure. We conclude that indomethacin and aspirin reduce unstimulated
gastric mucosal blood flow, suggesting that endogenous prostaglandin may
contribute to its maintenance.
