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Am J Physiol Gastrointest Liver Physiol 238: G419-G423, 1980;
0193-1857/80 $5.00
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AJP - Gastrointestinal and Liver Physiology, Vol 238, Issue 5 419-G423, Copyright © 1980 by American Physiological Society

ARTICLES

Transport of glucose and leucine by intestinal membrane vesicles in genetic diabetes

R. Bennetts and K. Ramaswamy

Na+-dependent D-glucose and L-leucine uptakes by isolated small intestinal brush-border membrane vesicles were studied in normal and genetically diabetic mice (C57BL/KsJ-dbm). Vesicles from normal mice demonstrated transport characteristics and morphological appearances identical to those from other mammalian small intestinal brush-border membrane isolates. There was no difference found between genetically diabetic mice and their littermate controls. These data suggest that the small intestinal brush-border membrane transport is not altered in genetic diabetes in contrast to that found in drug-induced diabetes.




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