AJP - Gastrointestinal and Liver Physiology, Vol 238, Issue 5 445-G452, Copyright © 1980 by American Physiological Society
Interpretation by theoretical model of dynamic and steady components in frog gustatory response
T. Kashiwagura, N. Kamo, K. Kurihara and Y. Kobatake
The behavior of dynamic component (slow component) and steady component of
the frog glossopharyngeal nerve response to CaCl2, measured in number of
impulses firing per second, was examined under various conditions. 1) The
magnitude of the dynamic component increased with the flow rate below about
0.3 ml/s, whereas that of the steady component was independent of the flow
rate. 2) The magnitude of the dynamic component increased with a rise of
temperature between 2.5 and 20 degrees C, whereas that of the steady
component was practically independent of temperature. Removal of Ca2+ from
the receptor membrane yielded a large dynamic component even at 2.5 degrees
C. 3) The treatment of the tongue with procaine led to a large reduction in
the magnitude of the dynamic component, whereas the effect of procaine on
the steady component was not pronounced. 4) The magnitude of the dynamic
component varied with the pH of the stimulating solution, whereas that of
steady component was practically independent of a pH between 4.5 and 7.5.
The above results were well interpreted by the following reaction scheme: S
(stimulus + A (receptor domain) in equilibrium (SA)active in equilibrium
(SA) inactive where (SA) active and (SA) inactive are active and inactive
complexes.
