AJP - Gastrointestinal and Liver Physiology, Vol 238, Issue 6 467-G477, Copyright © 1980 by American Physiological Society
Biosynthesis, segregation, and secretion of exportable proteins by the exocrine pancreas
G. A. Scheele
Recent findings that contribute to an understanding of the secretory
process in the pancreatic exocrine cell are reviewed. These include 1) the
separation, identification, and characterization of secreted proteins by
two-dimensional gel electrophoresis, 2) the intracellular route and
timetable of movement of secretory proteins from one intracellular
compartment to another, 3) the evidence that suggests that all enzymes and
zymogens secreted by the pancreas are segregated and transported within a
single intracellular pathway, and 4) the mechanism by which presecretory
proteins are thought to be transported across the lipid bilayer of the
rough endoplasmic reticulum (the transport peptide hypothesis).
