AJP - Gastrointestinal and Liver Physiology, Vol 238, Issue 6 509-G513, Copyright © 1980 by American Physiological Society
Local disorganization of interdigestive migrating complex by perfusion of a Thiry-Vella loop
C. Eeckhout, I. De Wever, G. Vantrappen and J. Janssens
In dogs, a 50-cm Thiry-Vella loop was perfused with different glucose
solutions (10-60%) and the effect on the interdigestive migrating
myoelectric complex was studied. The perfusions did not disrupt the
interdigestive pattern outside the loop, but produced a progressive
"fall-out" of phase III, related to the concentration of the glucose
solution. Quantitative analysis of the spike activity in the loop showed
that the interdigestive pattern was partially disrupted by the 10% glucose
solutions and that the 50 and 60% glucose perfusions induced a typical fed
pattern characterized by short periods of spike activity alternating with
short periods of quiescence. It was concluded that 1) perfusion of a
Thiry-Vella loop with glucose solutions changes the myoelectrical activity
of the loop from an interdigestive to a digestive pattern without
interfering with the migrating myopelectric complex outside the loop; and
2) this local disorganization must be mediated by factors interfering with
the effector mechanism in the loop.
