AJP - GI AJP: Endocrinology and Metabolism
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 239: G44-G48, 1980;
0193-1857/80 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kauffman, G. L.
Right arrow Articles by Grossman, M. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kauffman, G. L., Jr
Right arrow Articles by Grossman, M. I.

AJP - Gastrointestinal and Liver Physiology, Vol 239, Issue 1 44-G48, Copyright © 1980 by American Physiological Society

ARTICLES

Gastric bicarbonate secretion: effect of topical and intravenous 16,16-dimethyl prostaglandin E2

G. L. Kauffman Jr, J. J. Reeve Jr and M. I. Grossman

These studies were designed to compare intravenous and topical 16,16-dimethyl prostaglandin E2 (dmPGE2) as stimulants of gastric mucosal HCO3- secretion. In six Heidenhain pouch (HP) dogs, basal acid secretion was inhibited by cimetidine. With 100 ml 0.15 M NaCl as the fluid circulating through the HP, intrapouch titration to pH 6.0 was performed with 0.5 M HCl as titrant. After measuring basal HCO-3 secretion for 30 min, dmPGE2 was given intravenously or the fluid circulating in the HP was replaced by one containing dmPGE2. Intravenous dmPGE2 at infusion rates of 0, 0.5, 1.0, and 2.0 microgram . kg-1 . h-1 produced alkaline secretion rates of 34 +/- 9, 52 +/- 20, 72 +/- 21, and 70 +/- 20 (SE) mu mol . h-1, respectively. Topical dmPGE2 at concentrations of 0, 0.05, 1.25, and 2.50 microgram . ml-1 produced alkaline secretion rates of 22 +/- 7, 74 +/- 16, 134 +/- 28, and 144 +/- 35 mu mol . h-1, respectively (P less than 0,05 for each concentration). Glucosamine output, as an index of mucus secretion, increased significantly with HCO-3 secretion. We conclude that intragastric titration is a valid method for recording HCO-3 secretion from an HP, that topical dmPGE2 stimulates HCO3- secretion more effectively than intravenous dmPGE2, and that topical dmPGE2 stimulates mucus secretion as well as HCO-3 secretion,


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
N. Kanda, H. Seno, M. Kawada, T. Sawabu, Y. Uenoyoma, T. Nakajima, Y. Konda, H. Fukui, T. Takeuchi, and T. Chiba
Involvement of cyclooxygenase-2 in gastric mucosal hypertrophy in gastrin transgenic mice
Am J Physiol Gastrointest Liver Physiol, March 1, 2006; 290(3): G519 - G527.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online