AJP - Gastrointestinal and Liver Physiology, Vol 239, Issue 1 53-G58, Copyright © 1980 by American Physiological Society
Evidence for oscillation of prostaglandin release from spontaneously contracting guinea pig taenia coli
R. F. Coburn
Two strips of guinea pig taenia coli were mounted 1-2 mm apart in a small
organ bath. One of the strips was incubated before mounting with
indomethacin, which inhibited release of prostaglandin E2 for at least 4 h
to levels not detectable by biological assay. Both stretch-evoked
contractions or spontaneous contractions of the prostaglandin-releasing
strip reduced the contraction time intervals between spontaneous
contractions in the paired strip. Neither stretch-evoked nor spontaneous
contractions of the nonprostaglandin-releasing strip influenced spontaneous
contractions in the paired strip. With the strips widely separated,
stretch-evoked contractions of the prostaglandin-releasing strips caused
shortened contraction-time intervals in the paired strips, but spontaneous
contractions had no such effect. Rat fundus, separated 1-2 mm from
prostaglandin-releasing taenia coli, showed small contractions occurring at
the same frequency as spontaneous taenia contractions. These rat fundus
contractions were abolished by indomethacin. Data show that there is
communication between the prostaglandin-releasing strip and the
nonprogestaglandin-releasing strip, There is evidence that this
communication was mediated by released prostaglandin E2 and that release of
this mediated is augmented during spontaneous contractions of guinea pig
taenia coli.
