AJP - Gastrointestinal and Liver Physiology, Vol 239, Issue 4 324-G333, Copyright © 1980 by American Physiological Society
Action of theophylline on secretagogue-stimulated amylase release from dispersed pancreatic acini
L. Y. Korman, M. D. Walker and J. D. Gardner
In dispersed acini from guinea pig pancreas, theophylline did not alter
basal amylase release, but had three functionally distinct modes of action
on the stimulation of amylase release caused by various secretagogues. 1)
At relatively low concentrations (0.1-1.0 mM), theophylline augmented the
increase in enzyme secretion caused by vasoactive intestinal peptide,
secretin, or 8-bromoadenosine 3',5'-monophosphate, but did not alter the
increase in amylase release caused by other secretagogues. 2) At
intermediate concentrations (1-10 mM), theophylline selectively altered the
increase in enzyme secretion caused by carbamylcholine, but did not alter
the effects of cholecystokinin or bombesin, secretagogues whose modes of
action are similar to that of cabamylcholine. 3) At high concentrations
(greater than 10 mM), theophylline inhibited the increase in enzyme
secretion caused by all secretagogues tested.
