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Am J Physiol Gastrointest Liver Physiol 239: G511-G515, 1980;
0193-1857/80 $5.00
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AJP - Gastrointestinal and Liver Physiology, Vol 239, Issue 6 511-G515, Copyright © 1980 by American Physiological Society

ARTICLES

Clearance of circulating anionic and cationic pancreatic trypsinogens in the rat

J. W. Brodrick, C. Largman, M. C. Geokas, M. O'Rourke and S. B. Ray

The kinetics and mechanism of clearance of pancreatic cationic and anionic trypsinogens from the circulation have been investigated in a rat model. 125I-labeled rat cationic trypsinogen is cleared from the bloodstream with a half-life of approximately 4 min. In contrast, 125I-labeled rat anionic trypsinogen has a half-life in the circulation of approximately 55-60 min. The major site of clearance for both enzymes is the kidney. Neither zymogen binds to plasma proteins to a significant extent over a period of three half-lives. The relative rates of clearance of these zymogens from the circulation appears to correlate with their respective isoelectric points.




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