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Am J Physiol Gastrointest Liver Physiol 239: G532-G535, 1980;
0193-1857/80 $5.00
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AJP - Gastrointestinal and Liver Physiology, Vol 239, Issue 6 532-G535, Copyright © 1980 by American Physiological Society

ARTICLES

Suppression of gastric acid secretion by furosemide in isolated gastric mucosa of guinea pig

A. Ayalon, A. Corcia, G. Klemperer and S. R. Caplan

The effect of furosemide on acid secretion and Cl- transport was studied in isolated fundic mucosa of the guinea pig. Furosemide (10(-3) M), applied to the serosal side produced an immediate effect on the short-circuit current (Isc), lowering it by 47 +/- 2%. Potential difference decreased by 29 +/- 3%, electrical conductance by 18 +/- 4%, acid secretion by 38 +/- 1%, and net flux of Cl- from serosal-to-mucosal side by 37%. Application of the drug to the mucosal side produced similar effects on acid secretion and on the electrical parameters. It is suggested that furosemide blocks the entrance of Cl-, by the Na+--Cl- cotransport mechanism, through the basolateral membrane of the secreting cell. The consequent reduction in electrogenic Cl- transport would cause Isc and acid secretion to decrease. A reduction of Cl- conductance of the apical membrane, upon mucosal application of the drug, would cause similar effects on acid secretion and Cl- transport.


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