AJP - Gastrointestinal and Liver Physiology, Vol 240, Issue 3 221-G224, Copyright © 1981 by American Physiological Society
Postprandial hormonal inhibition of canine interdigestive gastric motility
J. C. Schang, K. A. Kelly and V. L. Go
Our aim was to determine whether hormones other than gastrin inhibit cyclic
interdigestive motility in the proximal stomach. In four conscious dogs
with autotransplanted proximal gastric pouches, excluded gastric antrums,
and chronic duodenal electrodes, intraluminal pressure of the pouch and
electrical activity of the duodenum were monitored before and after gastric
instillation of 250 ml of 154 mM NaCl alone or 154 mM NaCl plus 15 kcal/kg
of either dextrose, olive oil, casein hydrolysate, or a mixture containing
5 kcal/kg of each of the three nutrients. Dextrose, olive oil, casein, and
the mixture abolished the interdigestive cycles in both pouch and duodenum
and decreased intrapouch pressure compared with the saline control. The
duration of the inhibition was longest with oil (5 h) and shortest with
casein (3 h), and the decrease in mean intrapouch pressure was greatest
with the mixture (11.8 cmH2O . min) and least with dextrose (9.3 cmH2O .
min). Serum gastrin was unchanged by any of the instillates. We concluded
that hormones other than gastrin inhibited cyclic interdigestive motility
in the proximal stomach.
