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Am J Physiol Gastrointest Liver Physiol 241: G191-G195, 1981;
0193-1857/81 $5.00
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AJP - Gastrointestinal and Liver Physiology, Vol 241, Issue 2 191-G195, Copyright © 1981 by American Physiological Society

ARTICLES

Does endogenous prostaglandin affect gastric antral motility?

K. M. Sanders and J. H. Szurszewski

Intracellular electrical activity and muscle contraction were recorded simultaneously from circular muscle of the canine antrum. Treatment with indomethacin enhanced the plateau phase of the spontaneously occurring gastric action potential and the amplitude of the phasic contraction. Exogenous PGE2 reversed this effect of indomethacin. Treatment with indomethacin also enhanced the electrical and mechanical responses to pentagastrin; this enhancement was also reversed by PGE2. Considered together, these results suggest that endogenous prostaglandin, probably of the E series, tonically suppresses the spontaneous electrical and mechanical activities of antral circular muscle and the responsiveness of the muscle to excitatory stimuli.


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[Abstract] [Full Text] [PDF]


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