AJP - Gastrointestinal and Liver Physiology, Vol 241, Issue 2 98-103, Copyright © 1981 by American Physiological Society
Variation in canine exocrine pancreatic secretory activity during the interdigestive state
Z. Itoh, I. Takahashi, M. Nakaya and T. Suzuki
Interdigestive changes in pancreatic volume flow, gastric motor activity,
and intraduodenal pH were monitored automatically in eight dogs. As a
result, two different periods of pancreatic secretion were found to occur
alternately during the interdigestive state: one a secretory period (2.2
+/- 0.32 ml/10 min with high protein and low bicarbonate concentration) and
the other a nonsecretory period. The secretory period corresponded to the
interdigestive phase II and III contraction period in the stomach, and the
nonsecretory period coincided with the motor quiescent period in the
stomach. However, another secretory period was identified during the
interdigestive state; it occurred when the intraduodenal pH went below 7.0,
and no typical interdigestive contractions were observed in the stomach.
The secretory rate was 3.7 +/- 0.33 ml/10 min and was low in protein and
high in bicarbonate concentration. The present study demonstrates that
basal pancreatic secretory activity is never uniform but fluctuates with
motor events in the stomach. However, its control mechanism remains unknown
at present.
