AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 241: G248-G252, 1981;
0193-1857/81 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Swabb, E. A.
Right arrow Articles by Jordan, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Swabb, E. A.
Right arrow Articles by Jordan, L.

AJP - Gastrointestinal and Liver Physiology, Vol 241, Issue 3 248-G252, Copyright © 1981 by American Physiological Society

ARTICLES

Reversal of cholera toxin-induced secretion in rat ileum by luminal berberine

E. A. Swabb, Y. H. Tai and L. Jordan

The effect of luminal berberine hydrochloride concentration on cholera toxin-induced water and electrolyte secretion and on normal water and electrolyte transport was determined in vivo in the cannulated, perfused rat ileum using [14C]polyethylene glycol as a nonabsorbable marker. Berberine reduced the cholera toxin-induced secretion of water, Na, Cl, and calculated residual ion (primarily HCO3) in a concentration-dependent manner. The effect of berberine on cholera toxin-induced ileal secretion was evident 60-80 min after exposure and was reversed 60-80 min after removal of berberine from the perfusate. Mild changes in mucosal histology (villous tip edema) due to cholera toxin were also reversed by berberine. Berberine did not significantly alter normal ileal water and electrolyte transport.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online