AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 241: G275-G288, 1981;
0193-1857/81 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Powell, D. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Powell, D. W.

AJP - Gastrointestinal and Liver Physiology, Vol 241, Issue 4 275-G288, Copyright © 1981 by American Physiological Society

ARTICLES

Barrier function of epithelia

D. W. Powell

The ability of an epithelium to prevent permeation of noxious agents has not been well studied except in the gastrointestinal tract where exclusion of H+ has clinical significance. This article reviews the permeation routes across epithelia both as elucidated in the extensive electrophysiological work done in recent years and as demonstrated in morphological studies. We thus place concepts about gastrointestinal barrier function into the framework of transport physiology. Both the permeability and permselectivity of epithelial barriers are reviewed here. The effects of physical agents (pressure and electric current), polyvalent cations, organic compounds with both specific (channel blocking) and nonspecific (detergent) membrane properties, cyclic nucleotides, microfilament-active agents, and particularly H+ on both the barrier function (permeability and permselectivity) and transport function of epithelia are considered. Based on the available data, an important role for active Na+ transport in the maintenance of the epithelial barrier function can be postulated.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
N. Thongon, L.-i. Nakkrasae, J. Thongbunchoo, N. Krishnamra, and N. Charoenphandhu
Prolactin stimulates transepithelial calcium transport and modulates paracellular permselectivity in Caco-2 monolayer: mediation by PKC and ROCK pathways
Am J Physiol Cell Physiol, May 1, 2008; 294(5): C1158 - C1168.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. K. Tipsmark, D. A. Baltzegar, O. Ozden, B. J. Grubb, and R. J. Borski
Salinity regulates claudin mRNA and protein expression in the teleost gill
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R1004 - R1014.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
L. Tradtrantip, P. Piyachaturawat, C. J. Soroka, K. Harry, A. Mennone, C. Mahagita, N. Ballatori, and J. L. Boyer
Phloracetophenone-induced choleresis in rats is mediated through Mrp2
Am J Physiol Gastrointest Liver Physiol, July 1, 2007; 293(1): G66 - G74.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
C. M. Van Itallie, S. Rogan, A. Yu, L. S. Vidal, J. Holmes, and J. M. Anderson
Two splice variants of claudin-10 in the kidney create paracellular pores with different ion selectivities
Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1288 - F1299.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. S. L. Yu, K. M. McCarthy, S. A. Francis, J. M. McCormack, J. Lai, R. A. Rogers, R. D. Lynch, and E. E. Schneeberger
Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells
Am J Physiol Cell Physiol, June 1, 2005; 288(6): C1231 - C1241.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
C. M. Van Itallie and J. M. Anderson
The Molecular Physiology of Tight Junction Pores
Physiology, December 1, 2004; 19(6): 331 - 338.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. T. Kahle, G. G. MacGregor, F. H. Wilson, A. N. Van Hoek, D. Brown, T. Ardito, M. Kashgarian, G. Giebisch, S. C. Hebert, E. L. Boulpaep, et al.
Paracellular Cl- permeability is regulated by WNK4 kinase: Insight into normal physiology and hypertension
PNAS, October 12, 2004; 101(41): 14877 - 14882.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
E. E. Schneeberger and R. D. Lynch
The tight junction: a multifunctional complex
Am J Physiol Cell Physiol, June 1, 2004; 286(6): C1213 - C1228.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
N. A. Tobey, C. M. Argote, S. S. Hosseini, and R. C. Orlando
Calcium-switch technique and junctional permeability in native rabbit esophageal epithelium
Am J Physiol Gastrointest Liver Physiol, June 1, 2004; 286(6): G1042 - G1049.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. A. Alvarado, A. Betanzos, L. Franse-Carman, J. Chen, and L. Gonzalez-Mariscal
Endothelia of Schlemm's canal and trabecular meshwork: distinct molecular, functional, and anatomic features
Am J Physiol Cell Physiol, March 1, 2004; 286(3): C621 - C634.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
C. Prosser, K. Stelwagen, R. Cummins, P. Guerin, N. Gill, and C. Milne
Reduction in heat-induced gastrointestinal hyperpermeability in rats by bovine colostrum and goat milk powders
J Appl Physiol, February 1, 2004; 96(2): 650 - 654.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
C. M. Van Itallie, A. S. Fanning, and J. M. Anderson
Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins
Am J Physiol Renal Physiol, December 1, 2003; 285(6): F1078 - F1084.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
J. L. Gookin, J. A. Galanko, A. T. Blikslager, and R. A. Argenzio
PG-mediated closure of paracellular pathway and not restitution is the primary determinant of barrier recovery in acutely injured porcine ileum
Am J Physiol Gastrointest Liver Physiol, November 1, 2003; 285(5): G967 - G979.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
E. E. Schneeberger
Claudins form ion-selective channels in the paracellular pathway. Focus on "Claudin extracellular domains determine paracellular charge selectively and resistance but not tight junction fibril architecture"
Am J Physiol Cell Physiol, June 1, 2003; 284(6): C1331 - C1333.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
O. R. Colegio, C. V. Itallie, C. Rahner, and J. M. Anderson
Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture
Am J Physiol Cell Physiol, June 1, 2003; 284(6): C1346 - C1354.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
W.-Y. Lui, D. Mruk, W. M Lee, and C. Y. Cheng
Sertoli Cell Tight Junction Dynamics: Their Regulation During Spermatogenesis
Biol Reprod, April 1, 2003; 68(4): 1087 - 1097.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
T. Ludwig, R. Ossig, S. Graessel, M. Wilhelmi, H. Oberleithner, and S. W. Schneider
The electrical resistance breakdown assay determines the role of proteinases in tumor cell invasion
Am J Physiol Renal Physiol, August 1, 2002; 283(2): F319 - F327.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
O. R. Colegio, C. M. Van Itallie, H. J. McCrea, C. Rahner, and J. M. Anderson
Claudins create charge-selective channels in the paracellular pathway between epithelial cells
Am J Physiol Cell Physiol, July 1, 2002; 283(1): C142 - C147.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
Y. Kiuchi-Saishin, S. Gotoh, M. Furuse, A. Takasuga, Y. Tano, and S. Tsukita
Differential Expression Patterns of Claudins, Tight Junction Membrane Proteins, in Mouse Nephron Segments
J. Am. Soc. Nephrol., April 1, 2002; 13(4): 875 - 886.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
T. Poutahidis, T. Tsangaris, G. Kanakoudis, I. Vlemmas, N. Iliadis, and D. Sofianou
Helicobacter pylori-induced Gastritis in Experimentally Infected Conventional Piglets
Vet. Pathol., November 1, 2001; 38(6): 667 - 678.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
B. L. Firestein and C. Rongo
DLG-1 Is a MAGUK Similar to SAP97 and Is Required for Adherens Junction Formation
Mol. Biol. Cell, November 1, 2001; 12(11): 3465 - 3475.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
J. M. Anderson
Molecular Structure of Tight Junctions and Their Role in Epithelial Transport
Physiology, June 1, 2001; 16(3): 126 - 130.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
M. Furuse, K. Furuse, H. Sasaki, and S. Tsukita
Conversion of Zonulae Occludentes from Tight to Leaky Strand Type by Introducing Claudin-2 into Madin-Darby Canine Kidney I Cells
J. Cell Biol., April 9, 2001; 153(2): 263 - 272.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
T. Horie, S. Awazu, Y. Itakura, and T. Fuwa
Alleviation by Garlic of Antitumor Drug-Induced Damage to the Intestine
J. Nutr., March 1, 2001; 131(3): 1071S - 1074.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Cell Physiol.Home page
Y. Ban and L. J. Rizzolo
Differential regulation of tight junction permeability during development of the retinal pigment epithelium
Am J Physiol Cell Physiol, September 1, 2000; 279(3): C744 - C750.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. M. Wiener, R. F. Hoyt Jr., J. R. Deleonardis, R. R. Clevenger, K. R. Jeffries, K. Nagashima, M. Mandel, J. Owens, M. Eckhaus, R. J. Lutz, et al.
Manometric changes during retrograde biliary infusion in mice
Am J Physiol Gastrointest Liver Physiol, July 1, 2000; 279(1): G49 - G66.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
Z. Muresan, D. L. Paul, and D. A. Goodenough
Occludin 1B, a Variant of the Tight Junction Protein Occludin
Mol. Biol. Cell, February 1, 2000; 11(2): 627 - 634.
[Abstract] [Full Text]

Home page
 J. Cell Biol.Home page
M. Furuse, H. Sasaki, and S. Tsukita
Manner of Interaction of Heterogeneous Claudin Species Within and Between Tight Junction Strands
J. Cell Biol., November 15, 1999; 147(4): 891 - 903.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
I. Lang and H. Martens
Na transport in sheep rumen is modulated by voltage-dependent cation conductance in apical membrane
Am J Physiol Gastrointest Liver Physiol, September 1, 1999; 277(3): G609 - G618.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. T. Taylor, N. Fueki, A. Agah, R. M. Hershberg, and S. P. Colgan
Critical Role of cAMP Response Element Binding Protein Expression in Hypoxia-elicited Induction of Epithelial Tumor Necrosis Factor-alpha
J. Biol. Chem., July 2, 1999; 274(27): 19447 - 19454.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. Zareie, R. Brattsand, P. M. Sherman, D. M. McKay, and M. H. Perdue
Improved Effects of Novel Glucocorticosteroids on Immune-Induced Epithelial Pathophysiology
J. Pharmacol. Exp. Ther., June 1, 1999; 289(3): 1245 - 1249.
[Abstract] [Full Text]

Home page
 J. Am. Soc. Nephrol.Home page
A. S. FANNING, L. L. MITIC, and J. M. ANDERSON
Transmembrane Proteins in the Tight Junction Barrier
J. Am. Soc. Nephrol., June 1, 1999; 10(6): 1337 - 1345.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Cell Physiol.Home page
Y. Koyama, T. Yamamoto, T. Tani, K. Nihei, D. Kondo, H. Funaki, E. Yaoita, K. Kawasaki, N. Sato, K. Hatakeyama, et al.
Expression and localization of aquaporins in rat gastrointestinal tract
Am J Physiol Cell Physiol, March 1, 1999; 276(3): C621 - C627.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
Y. Akiba and J. D. Kaunitz
Regulation of intracellular pH and blood flow in rat duodenal epithelium in vivo
Am J Physiol Gastrointest Liver Physiol, January 1, 1999; 276(1): G293 - G302.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. Zareie, D. M. McKay, G. G. Kovarik, and M. H. Perdue
Monocyte/macrophages evoke epithelial dysfunction: indirect role of tumor necrosis factor-alpha
Am J Physiol Cell Physiol, October 1, 1998; 275(4): C932 - C939.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
A. Hallgren, G. Flemstrom, and O. Nylander
Interaction between neurokinin A, VIP, prostanoids, and enteric nerves in regulation of duodenal function
Am J Physiol Gastrointest Liver Physiol, July 1, 1998; 275(1): G95 - G103.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
L. B. Zimmerhackl, F. Momm, G. Wiegele, and M. Brandis
Cadmium is more toxic to LLC-PK1 cells than to MDCK cells acting on the cadherin-catenin complex
Am J Physiol Renal Physiol, July 1, 1998; 275(1): F143 - F153.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
D. J. Philpott, D. M. McKay, W. Mak, M. H. Perdue, and P. M. Sherman
Signal Transduction Pathways Involved in Enterohemorrhagic Escherichia coli-Induced Alterations in T84 Epithelial Permeability
Infect. Immun., April 1, 1998; 66(4): 1680 - 1687.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
C. T. Taylor, S. J. Lisco, C. S. Awtrey, and S. P. Colgan
Hypoxia Inhibits Cyclic Nucleotide-Stimulated Epithelial Ion Transport: Role for Nucleotide Cyclases as Oxygen Sensors
J. Pharmacol. Exp. Ther., February 1, 1998; 284(2): 568 - 575.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
D. J. Philpott, C. A. Ackerley, A. J. Kiliaan, M. A. Karmali, M. H. Perdue, and P. M. Sherman
Translocation of verotoxin-1 across T84 monolayers: mechanism of bacterial toxin penetration of epithelium
Am J Physiol Gastrointest Liver Physiol, December 1, 1997; 273(6): G1349 - G1358.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
I. M. Rosenberg, M. Goke, M. Kanai, H.-C. Reinecker, and D. K. Podolsky
Epithelial cell kinase-B61: an autocrine loop modulating intestinal epithelial migration and barrier function
Am J Physiol Gastrointest Liver Physiol, October 1, 1997; 273(4): G824 - G832.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
V. Wong and B. M. Gumbiner
A Synthetic Peptide Corresponding to the Extracellular Domain of Occludin Perturbs the Tight Junction Permeability Barrier
J. Cell Biol., January 27, 1997; 136(2): 399 - 409.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online