AJP - Gastrointestinal and Liver Physiology, Vol 241, Issue 6 478-G486, Copyright © 1981 by American Physiological Society

ARTICLES

Permeability of gastric capillaries to small and large molecules

M. A. Perry, W. J. Crook and D. N. Granger

The permeability of capillaries in the stomach to small and large solutes was studied with the double-indicator diffusion technique in the dog stomach and by analysis of steady-state lymph and plasma samples in the cat stomach. The effective pore radius in gastric capillaries determined by indicator diffusion was 53 A, whereas steady-state lymph samples predicted a small-pore radius of 47 A. At the highest plasma flow rates studied (achieved by intra-arterial infusion of isoproterenol), indicator diffusion estimates of the permeability-surface area product for raffinose, inulin, and beta-lactoglobulin A were 140, 70, and 8 ml . min-1 . 100 g-1, respectively. The lymph studies indicate that gastric capillaries are more permeable than capillaries in the intestine and colon to albumin and larger molecules. The calculated effective large-pore radius of gastric capillaries was 250 A. The osmotic reflection coefficients (sigma d) ranged from 0.73 +/- 0.03 for albumin to 0.91 +/- 0.02 for beta-lipoprotein (120-A radius). The sigma d for total plasma protein was 0.78 +/- 0.03, indicating a substantial transcapillary oncotic pressure gradient, despite the greater permeability of these capillaries for macromolecules.

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