AJP - Gastrointestinal and Liver Physiology, Vol 242, Issue 2 177-G182, Copyright © 1982 by American Physiological Society
Plasma pancreatic trypsinogens in chronic renal failure and after nephrectomy
M. C. Geokas, R. Reidelberger, M. O'Rourke, E. Passaro Jr and C. Largman
The kidney has previously been shown to be a major site for the plasma
clearance of pancreatic trypsinogens in the rat. This study investigated
plasma concentrations of anionic and cationic trypsinogen in chronic renal
failure and anephric patients. Plasma concentrations were significantly
elevated in both groups of patients. Hemodialysis did not change their
plasma levels. The plasma levels of anionic and cationic trypsinogens were
highly correlated in patients and normal subjects; however, the relative
concentrations of anionic trypsinogen were significantly higher in renal
failure patients. This suggests that in patients with renal failure the
secondary clearance mechanisms for these plasma proteins more efficiently
clear cationic molecules. In normal dogs, intravenous infusion of synthetic
octapeptide of cholecystokinin (CCK-8) resulted in small transitory
increases in plasma trypsinogen levels. After nephrectomy, basal levels of
anionic and cationic trypsinogen were elevated, and intravenous infusion of
CCK-8 resulted in prolonged, high levels of plasma trypsinogens.
