AJP - Gastrointestinal and Liver Physiology, Vol 242, Issue 4 333-G336, Copyright © 1982 by American Physiological Society
A pattern for gastric emptying in mice
M. Moreto, L. Guzman and A. Diez
Gastric emptying was studied in CD-1 mice weighing 15-30 g. Mice were fed a
nonabsorbable test meal consisting of radioactive barium sulfate suspended
in 1.5% methylcellulose. The amount of test meal remaining in the stomach
was determined 1, 2, 5, and 10 min after the administration. The initial
rates of emptying were significantly higher in the groups weighing 15-20 g
body wt. In all groups, 50% of the radioactivity administered was emptied
in less than 5 min. The gastric emptying figures obtained were adjusted to
three general equations: exponential, hyperbolic, and parabolic. The best
correlation coefficients were obtained with the parabola, although this
pattern of emptying is not completely satisfactory because it has a minimum
before the 10th min. The comparison of the exponential and hyperbolic
patterns, in terms of both the correlation coefficients and the "starting
indexes," showed that the hyperbola describes the data more closely. No sex
differences were observed.
