AJP - Gastrointestinal and Liver Physiology, Vol 242, Issue 6 565-G569, Copyright © 1982 by American Physiological Society
Regulation of oxygen uptake in resting and pentagastrin-stimulated canine stomach
M. A. Perry, G. B. Bulkley, P. R. Kvietys and D. N. Granger
The relation between oxygen uptake and blood flow in the isolated dog
stomach was investigated under resting conditions and during intra-arterial
infusion of isoproterenol or pentagastrin. Blood flows above and below
control values were achieved by pump perfusion and partial arterial
occlusion, respectively. In the resting stomach oxygen uptake increased
from 0.4 to 1.5 ml.min-1.100 g-1 as blood flow increased from 4 to 40
ml.min-1.100 g-1 and then remained constant for blood flows up to 100
ml.min-1.100 g-1. Isoproterenol did not significantly alter the relation
between oxygen uptake and blood flow. In pentagastrin-stimulated stomachs
oxygen uptake was maintained at 2.5 ml.min-1.100 g-1 at blood flows between
40 and 100 ml.min-1.100 g-1 and decreased at blood flows below 40
ml.min-1.100 g-1. The results indicate that pentagastrin increases
oxidative metabolism in the stomach. Despite this increase in oxygen
consumption with pentagastrin, the general shape of the relation between
blood flow and oxygen uptake remained the same and was simply displaced
vertically above the control data.
