AJP - Gastrointestinal and Liver Physiology, Vol 242, Issue 6 603-G607, Copyright © 1982 by American Physiological Society
Duodenogastric reflux in the dog
A. Sonnenberg, S. A. Muller-Lissner, G. Schattenmann, J. R. Siewert and A. L. Blum
Duodenogastric reflux, gastric emptying, and gastric secretion were
measured simultaneously by a double-marker technique after instillation of
a liquid lipid meal (300 ml Intralipid) or a protein meal (300 ml
Bactopeptone) in five trained mongrel dogs. A lipid meal was emptied slower
and elicited less volume secretion than a protein meal. Duodenogastric
reflux rate and intragastric accumulation of duodenal contents were similar
with both meals. Intravenous infusion of atropine slowed gastric emptying
and inhibited gastric volume secretion only in the case of protein meal.
Atropine increased duodenogastric reflux rate and gastric accumulation of
duodenal contents with both protein and lipid meals. The percentage of
duodenal contents inside the stomach increased continuously during gastric
emptying; it did not exceed 20% with both meals given alone and 40% with
both meals given together with atropine. It is concluded that
duodenogastric reflux and gastric accumulation of duodenal contents are
common phenomena during gastric digestion of a meal. The degree of such
accumulation does not depend on the type of meal. Intragastric accumulation
of duodenal contents is increased when duodenogastric reflux rate is
stimulated and when gastric emptying rate is inhibited simultaneously.
