AJP - Gastrointestinal and Liver Physiology, Vol 243, Issue 1 10-G15, Copyright © 1982 by American Physiological Society

ARTICLES

Response of the exocrine pancreas to quantitative and qualitative variations in dietary lipids

B. Saraux, A. Girard-Globa, M. Ouagued and D. Vacher

In the rat, pancreatic amylase and, to a lesser extent, lipase adapt quantitatively to the amount of their respective substrates in the diet by an increase in specific activity and total contents (range of variation, fivefold for amylase and twofold for lipase). Colipase responded to protein intake (r = 0.85, P less than 0.01) and not to lipids provided protein intake was below 3.5 g or above 6.0 g. With this latter amount of protein, a maximal level was obtained, even with 2% lipid in the diet. Between 3.5 and 6.0 g, lipid intake was found to modulate colipase in parallel with lipase. When different types of fat were compared, the degree of saturation was found to have no impact on lipase, colipase, and amylase. Diets containing medium-chain triglycerides (C8-C10) did not maximally increase specific activity and total content of lipase and colipase, whereas they did not repress amylase as much longer chain triglycerides did. With coconut oil (45% C12), lipase was maximally stimulated but amylase was not maximally repressed, showing that the regulation of the hydrolases may be partly reciprocal and partly independent.

This article has been cited by other articles:

				M. S. Hedemann, A. R. Pedersen, and R. M. Engberg Exocrine Pancreatic Secretion Is Stimulated in Piglets Fed Fish Oil Compared with Those Fed Coconut Oil or Lard J. Nutr., December 1, 2001; 131(12): 3222 - 3226. [Abstract] [Full Text] [PDF]