AJP - Gastrointestinal and Liver Physiology, Vol 243, Issue 3 204-G207, Copyright © 1982 by American Physiological Society
Effect of pancreatic polypeptide on gallbladder pressure and hepatic bile secretion
T. E. Adrian, P. Mitchenere, G. Sagor and S. R. Bloom
Intraluminal gallbladder pressure, measured by radiotelemetry, and bile
output were monitored during infusion of porcine pancreatic polypeptide
(PP) at doses of 6, 25, 100, and 400 pmol . kg-1 . h-1 in healthy conscious
pigs. Plasma PP concentrations during infusion of the three lower doses,
measured by radioimmunoassay, were within the range seen postprandially in
these animals. Gallbladder pressure fell in a dose-related manner during PP
infusion by 2.2 +/- 0.9, 8.2 +/- 0.4, 11.6 +/- 0.7, and 14.8 +/- 0.8 mmHg,
respectively. In addition, a significant reduction in the bile output was
observed during infusion of the two higher doses of PP. In a separate
series of experiments, using cholecystectomized pigs, PP had no effect on
bile output. These findings suggest that the amount of PP released
postprandially may be sufficient to influence gallbladder function but not
hepatic secretion of bile in the pig.
