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Am J Physiol Gastrointest Liver Physiol 243: G455-G462, 1982;
0193-1857/82 $5.00
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AJP - Gastrointestinal and Liver Physiology, Vol 243, Issue 6 455-G462, Copyright © 1982 by American Physiological Society

ARTICLES

Autoradiographic and kinetic demonstration of acinar heterogeneity of taurocholate transport

G. M. Groothuis, M. J. Hardonk, K. P. Keulemans, P. Nieuwenhuis and D. K. Meijer

A combination of autoradiography of water-soluble compounds and normal and retrograde perfusions was used to study whether there was a heterogeneity in bile salt transport between zone 1 and zone 3 hepatocytes of the rat and, if so, whether such a heterogeneity was due to the localization of these cells in the liver blood-stream, to intrinsic cellular differences, or to both. When a low dose of [3H]taurocholate was administered under pentobarbital sodium anesthesia in vivo or to normally perfused livers, the label was localized primarily in zone 1; in livers perfused in a retrograde direction, it appeared predominantly in zone 3. High doses of [3H]taurocholate administered in vivo and in normal and retrograde perfusions resulted in a more homogeneous labeling of the acini. The plasma disappearance of [3H]taurocholate was similar in normal and retrograde perfusions, but in the latter biliary excretion occurred at a considerably slower rate. From these results it is concluded that at low doses bile salts are primarily transported by zone 1 cells. Zone 3 cells appear to be able to take up taurocholate with ease, but their biliary excretion is slower compared with zone 1 cells.


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