AJP - Gastrointestinal and Liver Physiology, Vol 243, Issue 6 543-G548, Copyright © 1982 by American Physiological Society
Renal response to captopril in conscious dogs pretreated with indomethacin
J. M. DeForrest, T. L. Waldron and M. J. Antonaccio
This study was designed to determine whether the prostaglandins mediate the
renal effects of captopril in the conscious sodium-replete dog. In a group
of control animals (n = 9), effective renal plasma flow (ERPF) increased
from 185 +/- 15 to 230 +/- 12 ml/min and plasma renin activity (PRA)
increased from 0.64 +/- 0.15 to 12.9 +/- 1.1 ng ANG I . ml-1 . h-1 after
captopril (10 mg/kg bolus plus 10 micrograms . kg-1 . min-1 i.v.)
administration. Glomerular filtration rate (GRF) and sodium excretion
(UnaV) were also increased significantly following captopril treatment,
whereas urine volume (V), potassium excretion (UkV), mean arterial pressure
(MAP), and heart rate (HR) remained unchanged throughout the experiment.
When the same dose of captopril was given to indomethacin-pretreated dogs
(5 mg/kg bolus plus 2 micrograms . kg-1 . min-1 i.v.), ERPF increased from
170 +/- 8 to 265 +/- 18 ml/min and PRA increased from 1.2 +/- 0.4 to 14.6
+/- 3.0 ng ANG I . ml-1 . h-1 after the captopril, while UnaV, UkV, and V
remained unchanged. These data demonstrate that the prostaglandins do not
mediate the ability of captopril to increase PRA or effective renal plasma
flow in this experimental model.
