AJP - Gastrointestinal and Liver Physiology, Vol 244, Issue 1 40-G45, Copyright © 1983 by American Physiological Society
Action of somatostatin on stomach, pancreas, gastric mucosal blood flow, and hormones
T. M. Lin, D. C. Evans, C. J. Shaar and M. A. Root
In dogs gastric secretion induced by tetragastrin and pancreatic secretion
induced by secretin and/or cholecystokinin were inhibited by somatostatin
at doses of 0.06-1 microgram X kg-1 X h-1 and 0.06-1 microgram X kg-1 X 0.5
h-1, respectively. Inhibition was a linear function of the logarithm of
dose. Basal and 2-deoxy-D-glucose-induced gastric acid secretion was also
significantly inhibited by low doses of somatostatin. Results in this study
differ from those reported previously by clarifying the action of
somatostatin as follows. 1) The inhibitory effect of somatostatin on
pancreatic protein secretion was significantly greater than that on water
and bicarbonate production. Somatostatin was more effective on
cholecystokinin- than secretin-induced pancreatic secretion. 2) Although
gastric mucosal blood flow (MBF) was affected by somatostatin, the
reduction of MBF was not the primary mechanism responsible for its
inhibitory action. 3) The low doses of somatostatin used in this study
significantly inhibited gastric and pancreatic secretion without affecting
the basal plasma concentrations of insulin, glucagon, growth hormone,
gastrin, or secretin in the dogs, suggesting that the inhibitory action was
not mediated by changes or reduction in plasma concentration of these
hormones.
