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Am J Physiol Gastrointest Liver Physiol 244: G107-G110, 1983;
0193-1857/83 $5.00
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AJP - Gastrointestinal and Liver Physiology, Vol 244, Issue 2 107-G110, Copyright © 1983 by American Physiological Society

ARTICLES

What is meant by the term "bile acid"?

L. Roger, J. St Pyrek, J. M. Little and E. W. Adcock

The bile acids are a set of acidic steroids. Many conventional bile acids share a common derivation and have functional characteristics in common. Exceptions exist, however, to virtually all of the rules that can be applied to a definition of bile acids. The term is thus best applied to those steroids with a side chain at C-17, which contains a carboxylic acid group, and to acidic derivatives of such compounds. Naturally occurring bile acids are a more numerous and diverse group than has been generally recognized. The site of origin, synthetic pathways, metabolism, and bioactivity of recently recognized unconventional bile acids are under intensive investigation.




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