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Am J Physiol Gastrointest Liver Physiol 244: G254-G260, 1983;
0193-1857/83 $5.00
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AJP - Gastrointestinal and Liver Physiology, Vol 244, Issue 3 254-G260, Copyright © 1983 by American Physiological Society

ARTICLES

Fate of circulating isoamylases in the rabbit

J. L. Rosenblum, T. E. Niesen, B. K. Raab and D. H. Alpers

Amylase purified from the pancreas and parotid gland of rabbits was labeled with 125I. Plasma disappearance was biexponential after bolus injection. Half-time of metabolic clearance was 97 and 95 min, respectively, for pancreatic and salivary 125I-amylase. About 20 and 30% of the injected pancreatic and salivary 125I-amylase, respectively, appeared intact in the urine within 24 h. Organs were assayed for radioactivity at specified times. No organ at any time contained more than 20% of injected radioactivity. At 24 h, more than 90% of radioactivity in organs was acid soluble. Bilateral nephrectomy significantly slowed plasma disappearance, although 90% hepatectomy did not. These studies in the rabbit indicate that 1) homologous isoamylases are cleared from plasma at rates comparable with those reported in primates; 2) in contrast to primates, urinary excretion of salivary amylase is greater than pancreatic amylase; and 3) within 24 h, virtually all of injected 125I-labeled isoamylases were catabolized or excreted.


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