AJP - GI Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 244: G578-G582, 1983;
0193-1857/83 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gumucio, J. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gumucio, J. J.

AJP - Gastrointestinal and Liver Physiology, Vol 244, Issue 6 578-G582, Copyright © 1983 by American Physiological Society

ARTICLES

Functional and anatomic heterogeneity in the liver acinus: impact on transport

J. J. Gumucio

The site of solute exchange between blood and hepatocytes is the liver acinus, the structural and functional unit of hepatic parenchyma. Because the perfusion of acinar hepatocytes occurs in a sequential manner, differences in solute concentration between hepatocytes located at the inlet (zone 1) and at the outlet (zone 3) of the acinus are predictable. However, the distribution and transport of solutes by hepatocytes of each acinar zone also seem to be influenced by factors other than the sequential perfusion of blood. The concentration of receptors in hepatocytes at each zone, the presence of specific chemical groups on the incoming molecules, and the binding of the solutes to plasma protein are all factors that modify the interaction with, and the cellular concentration attained by, solutes in each acinar zone. Therefore, solute concentration in hepatocytes of each acinar zone may produce a profile of decreasing solute concentration from cells in zone 1 to those in zone 3, a reverse profile from zone 3 to zone 1, or a similar concentration in all hepatocytes.


This article has been cited by other articles:


Home page
 Drug Metab. Dispos.Home page
T. N. Abu-Zahra, A. W. Wolkoff, R. B. Kim, and K. S. Pang
Uptake of Enalapril and Expression of Organic Anion Transporting Polypeptide 1 in Zonal, Isolated Rat Hepatocytes
Drug Metab. Dispos., July 1, 2000; 28(7): 801 - 806.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online