AJP - Gastrointestinal and Liver Physiology, Vol 244, Issue 6 668-G674, Copyright © 1983 by American Physiological Society
Intestinal transudation, secretion, and lymph flow during volume expansion in the rat
J. S. Lee
The effect of volume expansion by intravenous infusion of saline on the
rate of intestinal lymph flow (JL), serosal surface transudation (JT), and
secretion (JS) from upper jejunum was determined. During saline infusion
there was a large increase in JS and JT but a small increase in JL due to
increased capillary filtration. About 20% of JL from the main intestinal
lymph duct originated from the intestine and the rest from the mesenteric
pedicle. JL (corrected for pedicle lymph flow), JT, and JS were estimated
to account for 10, 30, and 60% of capillary filtrate from the intestine,
respectively. Neither lymph nor secretion contained measurable protein, but
transudation had a high protein concentration about half of that in the
plasma. From these findings it is inferred that probably both JL and JS
were derived from the capillary filtrate of mucosa and submucosa vascular
beds and JT from that of muscular vascular bed and that capillaries and
venules in the mucosa restricted the passage of protein molecules while
those of the intestinal muscular tissue were highly permeable to protein.
