AJP - Gastrointestinal and Liver Physiology, Vol 245, Issue 2 297-G300, Copyright © 1983 by American Physiological Society
Effect of luminal somatostatin on pentagastrin-stimulated gastric acid secretion in the rat
R. Morz, J. Prager-Petz and H. Pointner
The perfused rat stomach was used to investigate the effect of
intragastrically administered somatostatin (S-14) on basal and
pentagastrin-stimulated gastric acid secretion. Intravenous injection of
pentagastrin (10 micrograms/kg body wt) induced a peak acid output (PAO) of
6.3 +/- 0.45 mu eq H+. With luminal perfusion of the stomach by S-14 (100
micrograms X kg-1 X min-1), no significant inhibition of gastric acid
secretion was observed (PAO: 5.9 +/- 0.6 mu eq H+). The same dose of S-14
administered intravenously significantly inhibited acid secretion (PAO: 1.7
+/- 0.4 mu eq H+) as did intravenous injection of neutralized
S-14-containing gastric perfusate obtained by perfusion from a different
rat stomach (PAO: 1.9 +/- 0.5 mu eq H+). Intravenous injection of a saline
gastric perfusate containing no S-14 did not alter gastric acid secretion
(PAO: 6.3 +/- 0.7 mu eq H+). It is concluded that S-14 does inhibit gastric
acid secretion when administered systemically but not by intraluminal
application.
