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Am J Physiol Gastrointest Liver Physiol 245: G313-G320, 1983;
0193-1857/83 $5.00
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AJP - Gastrointestinal and Liver Physiology, Vol 245, Issue 2 313-G320, Copyright © 1983 by American Physiological Society

ARTICLES

Biological activity of canine intestinal cholecystokinin-58

V. E. Eysselein, C. W. Deveney, H. Sankaran, J. R. Reeve Jr and J. H. Walsh

The biological activity of a recently characterized cholecystokinin molecule, canine CCK-58, has been tested using perifused canine gallbladder strips and isolated mouse pancreatic acini. It has been shown that canine CCK-58, purified by affinity chromatography and molecular sieve chromatography, is biologically as potent as canine CCK-39,33 (component II) and synthetic CCK-8. The biological responses were inhibited by dibutyryl cGMP, a known CCK antagonist. CCK-58 is one of the main large molecular forms of CCK in the intestine mucosa. Whether CCK-58 is only an intracellular precursor of other CCK molecules or an important circulating hormone cannot be determined from the data currently available.




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