AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 245: G808-G815, 1983;
0193-1857/83 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Freel, R. W.
Right arrow Articles by Goldner, A. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Freel, R. W.
Right arrow Articles by Goldner, A. M.

AJP - Gastrointestinal and Liver Physiology, Vol 245, Issue 6 808-G815, Copyright © 1983 by American Physiological Society

ARTICLES

Dihydroxy bile salt-induced alterations in NaCl transport across the rabbit colon

R. W. Freel, M. Hatch, D. L. Earnest and A. M. Goldner

The effects of increasing mucosal or serosal concentrations (1-4 mM) of taurochenodeoxycholate (TCDC) on sodium chloride transport across the isolated, short-circuited rabbit colon were examined. Mucosal TCDC produced dose-related increases in tissue conductance (Gt) and the unidirectional fluxes of Na+ and Cl- and dose-related decreases in net NaCl absorption. At 4 mM mucosal TCDC, Gt was increased fivefold, net sodium flux (JNanet) was reduced 50%, and JClnet was abolished. Serosal TCDC also produced dose-dependent changes in permeability that were quantitatively different. Four millimolar serosal TCDC produced a 2.7-fold increase in Gt, abolished JNanet, and stimulated electrogenic Cl- secretion. TCDC-induced Cl- secretion was stimulated by 10(-5) M serosal TCDC, inhibited by serosal furosemide or ouabain, did not alter theophylline-induced secretion (and vice versa), and occurred in the absence of serosal Ca2+. It is suggested that 1) TCDC inhibition of sodium absorption is indirect (i.e., not simply due to a reduction in the activity of the Na "pump," since Cl- secretion persists during conditions that abolish JNanet) and 2) TCDC induces Cl- secretion by enhancing the activity of basolateral membrane adenylate cyclase.


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
A. T. Blikslager, A. J. Moeser, J. L. Gookin, S. L. Jones, and J. Odle
Restoration of Barrier Function in Injured Intestinal Mucosa
Physiol Rev, April 1, 2007; 87(2): 545 - 564.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
C. Okolo, T. Wong, M. W. Moody, and T. D. Nguyen
Effects of bile acids on dog pancreatic duct epithelial cell secretion and monolayer resistance
Am J Physiol Gastrointest Liver Physiol, November 1, 2002; 283(5): G1042 - G1050.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. Venkatasubramanian, N. Selvaraj, M. Carlos, S. Skaluba, M. M. Rasenick, and M. C. Rao
Differences in Ca2+ signaling underlie age-specific effects of secretagogues on colonic Cl{-} transport
Am J Physiol Cell Physiol, March 1, 2001; 280(3): C646 - C658.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online