AJP - Gastrointestinal and Liver Physiology, Vol 246, Issue 2 173-G179, Copyright © 1984 by American Physiological Society
Interaction between stimulants of exocrine pancreatic secretion in dogs
C. Beglinger, M. I. Grossman and T. E. Solomon
We measured bicarbonate and protein secretory responses to graded doses of
intravenous caerulein and bethanechol and intraduodenal L-phenylalanine
alone or with background secretin; graded doses of secretin alone or with
background caerulein or L-phenylalanine; and background secretin plus
graded doses of caerulein or L-phenylalanine plus background atropine
sulfate. Potentiation (more-than-additive response) occurred for
bicarbonate secretion between secretin and caerulein, between secretin and
L-phenylalanine, but not between secretin and bethanechol. The only
potentiating interaction for protein secretion was between secretin and low
doses of caerulein. Atropine abolished the potentiated bicarbonate response
to secretin plus L-phenylalanine but had no effect on the response to
secretin plus caerulein. Potentiation between secretin and cholinergic
mechanisms and cholecystokinin for pancreatic bicarbonate secretion may be
an important regulatory mechanism, while potentiation of protein secretion
with these stimulants does not appear to be important in dogs. A
cholinergic mechanism mediates much of the bicarbonate potentiation between
secretin and intestinal L-phenylalanine.
