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Am J Physiol Gastrointest Liver Physiol 246: G342-G345, 1984;
0193-1857/84 $5.00
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AJP - Gastrointestinal and Liver Physiology, Vol 246, Issue 4 342-G345, Copyright © 1984 by American Physiological Society

ARTICLES

Effects of peptides on gastric emptying

A. W. Mangel and A. Koegel

The effects of peptides on gastric emptying of a liquid meal were studied in rats. Gastric emptying was found to be delayed following intraperitoneal injection of the octapeptide of cholecystokinin (CCK-8). Vasoactive intestinal peptide did not effect emptying, while substance P and neurotensin caused a moderate acceleration in gastric emptying. After oral administration of a solution containing the amino acids tryptophan and phenylalanine, but not glycine, a statistically significant inhibition of gastric emptying was observed. Our results suggest an involvement of CCK in the regulation of gastric emptying.




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