AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 247: G352-G356, 1984;
0193-1857/84 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dembinski, A. B.
Right arrow Articles by Johnson, L. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dembinski, A. B.
Right arrow Articles by Johnson, L. R.

AJP - Gastrointestinal and Liver Physiology, Vol 247, Issue 4 352-G356, Copyright © 1984 by American Physiological Society

ARTICLES

Stimulation of mucosal growth by a dietary amine

A. B. Dembinski, T. Yamaguchi and L. R. Johnson

Nutrients are believed to have a direct trophic effect on the cells of the gastrointestinal mucosa. However, no normal constituent of the diet has ever been shown to stimulate mucosal growth when administered orally. Sham-operated and antrectomized rats were fed 20 g of powdered commercial rat pellets daily or 20 g of food containing dimethylamine (100 mumol/g food). After 7 days rats were killed and growth of the mucosa of the oxyntic gland portion of the stomach and 2-cm segments of duodenum, jejunum, and proximal colon was determined. Antrectomy resulted in significant decreases in the weight and the DNA, RNA, and protein content of all four tissues and serum gastrin levels. Feeding amines abolished the differences in the oxyntic gland and duodenal mucosa. In general, the effect of amines decreased distally. Feeding amines did not significantly alter serum gastrin levels. These data indicate that dietary amines may directly stimulate the growth of gastrointestinal mucosa. These results may explain some of the proximal-to-distal gradients described for the growth of the mucosa.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
W. Deng, M. J. Viar, and L. R. Johnson
Polyamine depletion inhibits irradiation-induced apoptosis in intestinal epithelia
Am J Physiol Gastrointest Liver Physiol, September 1, 2005; 289(3): G599 - G606.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online