AJP - Gastrointestinal and Liver Physiology, Vol 248, Issue 1 118-G123, Copyright © 1985 by American Physiological Society

ARTICLES

Peptide YY inhibits meal-stimulated pancreatic and gastric secretion

T. N. Pappas, H. T. Debas, Y. Goto and I. L. Taylor

Peptide YY was recently isolated from porcine intestine and shown to exhibit marked structural homology with pancreatic polypeptide, a potent inhibitor of pancreatic exocrine secretion. We have examined the effects of infused peptide YY on gastric and pancreatic secretion in four mongrel dogs with gastric and pancreatic fistulas. A 15% liver extract meal was instilled intragastrically, and normal saline or one of three doses of peptide YY (200, 400, and 800 pmol X kg-1 X h-1) was infused into a peripheral vein. All three doses of peptide YY significantly inhibited meal-stimulated pancreatic fluid and bicarbonate secretion, with the lowest dose inhibiting secretion by 44.5 +/- 3.5 and 53.6 +/- 8.5%, respectively. Pancreatic protein secretion and gastric acid secretion were significantly inhibited by the two highest doses. The 200, 400, and 800 pmol X kg-1 X h-1 doses of peptide YY were associated with increments in peripheral blood of 201 +/- 24, 357 +/- 50, and 971 +/- 139 pM, respectively. These values compared with mean increments of 86.3 +/- 8.5 pM after a meat meal and 403 +/- 63 pM after intestinally perfused oleic acid. The present studies demonstrate that peptide YY inhibits gastric and pancreatic secretion and suggest that peptide YY may be the gastric and pancreatic inhibitor in ileocolonic mucosa that is released by perfusion of the intestine with oleic acid.

This article has been cited by other articles:

				S. Jakob, R. Mosenthin, R. Zabielski, C. Rippe, M. S. Winzell, U. Gacsalyi, D. Laubitz, E. Grzesiuk, and S. G. Pierzynowski Fats Infused Intraduodenally Affect the Postprandial Secretion of the Exocrine Pancreas and the Plasma Concentration of Cholecystokinin but Not of Peptide YY in Growing Pigs J. Nutr., October 1, 2000; 130(10): 2450 - 2455. [Abstract] [Full Text]

				K. Sonoyama, K. Suzuki, and T. Kasai Peptide YY Stimulates the Expression of Apolipoprotein A-IV Gene in Caco-2 Intestinal Cells Experimental Biology and Medicine, March 1, 2000; 223(3): 270 - 275. [Abstract] [Full Text]

				K. Sonoyama, K. Tajima, R. Fujiwara, and T. Kasai Intravenous Infusion of Hexamethonium and Atropine But Not Propranolol Diminishes Apolipoprotein A-IV Gene Expression in Rat Ileum J. Nutr., March 1, 2000; 130(3): 637 - 641. [Abstract] [Full Text]

				X.-T. Zhao, J. H. Walsh, H. Wong, L. Wang, and H. C. Lin Intestinal fat-induced inhibition of meal-stimulated gastric acid secretion depends on CCK but not peptide YY Am J Physiol Gastrointest Liver Physiol, February 1, 1999; 276(2): G550 - G555. [Abstract] [Full Text] [PDF]

				T E BOWLING and D B A SILK Colonic responses to enteral tube feeding Gut, February 1, 1998; 42(2): 147 - 151. [Full Text] [PDF]

				C. A. Blaze, P. J. Mannon, S. R. Vigna, A. R. Kherani, and B. A. Benjamin Peptide YY receptor distribution and subtype in the kidney: effect on renal hemodynamics and function in rats Am J Physiol Renal Physiol, October 1, 1997; 273(4): F545 - F553. [Abstract] [Full Text] [PDF]