AJP - Gastrointestinal and Liver Physiology, Vol 248, Issue 4 407-G417, Copyright © 1985 by American Physiological Society
Tauroursodeoxycholate prevents biliary protein excretion induced by other bile salts in the rat
K. Kitani, M. Ohta and S. Kanai
Biliary excretion of various proteins (5'-nucleotidase, alkaline
phosphatase, lactate dehydrogenase, and albumin) was investigated in
pentobarbital sodium-anesthetized rats infused with different bile salts
[taurocholate (TC), taurochenodeoxycholate (TCDC), and
tauroursodeoxycholate (TUDC)]. A TCDC infusion at 0.4 mumol . min-1 . 100 g
body wt-1 caused much higher increases in the biliary excretion of these
proteins compared with the respective values in rats that received an
infusion of TC at a threefold higher rate (1.2 mumol . min-1 . 100 g body
wt-1). In contrast, a TUDC infusion at 1.8 mumol . min-1 . 100 g body wt-1
showed the minimum effect on these protein leakages. A combined infusion of
TCDC (0.4 mumol . min-1 . 100 g-1) and TUDC (0.6 mumol . min-1 . 100 g-1)
resulted in drastic (8- to 20-fold) decreases in excretion of these enzymes
and albumin compared with respective values in rats infused with TCDC
alone. Similar preventive effects were observed with the addition of TUDC
to the infusion of TC (1.2 mumol . min-1 . 100 g-1). These results suggest
that the hepatic cytotoxic effects of TC and TCDC can be prevented by the
simultaneous infusion of TUDC in rats.
