AJP - Gastrointestinal and Liver Physiology, Vol 250, Issue 4 511-G517, Copyright © 1986 by American Physiological Society
Effects of NaSCN and omeprazole on resistance and potential of fundus of Rana pipiens
W. S. Rehm, G. Carrasquer and M. Schwartz
Thiocyanate (SCN) produced a rapid inhibition of acid secretion and a
concurrent rapid increase in the transmucosal potential difference (PD) and
resistance. After inhibition, resistance rapidly peaked and then decreased.
In contrast, omeprazole produced a slow inhibition of secretion and a slow
increase in PD and resistance. The peak increase in resistance with SCN was
significantly greater than the steady-state increases for both SCN and
omeprazole. All increases were significant. The increases in PD and
resistance are greater at high H+ rates than at low H+ rates. We postulate
that the peak SCN increase in resistance is due to the increase in
resistance of the secretory membrane, which is followed by a decrease in
resistance of the nutrient membrane. On this basis the omeprazole increase
in resistance that occurs concurrently with the slow decrease in the H+
rate is a result of a concurrent change of the resistances of the two
opposing membranes.
