AJP - GI AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 251: G111-G116, 1986;
0193-1857/86 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tseng, C. C.
Right arrow Articles by Johnson, L. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tseng, C. C.
Right arrow Articles by Johnson, L. R.

AJP - Gastrointestinal and Liver Physiology, Vol 251, Issue 1 111-G116, Copyright © 1986 by American Physiological Society

ARTICLES

Role of thyroxine in functional gastric development

C. C. Tseng and L. R. Johnson

The role of thyroxine (T4) on the functional development of chief and parietal cells was studied in the rat. Daily injection of thyroxine (0.1 microgram/g body wt) resulted in the precocious appearance of pepsinogen in the oxyntic gland mucosa and an increase in basal acid output. Thyroxine had no effect in adrenalectomized rats. In propylthiouracil-induced hypothyroid pups, pepsinogen content and basal acid secretion were low. Corticosterone acetate (200 micrograms/g body wt) injection increased pepsinogen content and basal acid secretion in the absence of normal levels of thyroid hormones. We conclude that the effect of thyroxine on the development of chief and parietal cells is primarily due to accompanying changes in serum corticosterone.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online