AJP - Gastrointestinal and Liver Physiology, Vol 251, Issue 5 649-G655, Copyright © 1986 by American Physiological Society
Effects of micellar oleic acid on canine jejunal blood flow and neurotensin release
R. H. Gallavan Jr, C. Shaw, R. F. Murphy, K. D. Buchanan, S. N. Joffe and E. D. Jacobson
The purpose of this study was to evaluate the role of neurotensin in the
local regulation of the lipid-induced jejunal hyperemia. Total blood flow
and the arteriovenous hormone concentration difference were measured in
isolated jejunal loops of anesthetized dogs with either saline, bile (10%
in normal saline), oleic acid (40 mM in normal saline), or oleic acid and
bile in the lumen. The bile-oleic acid mixture produced a sustained
increase (+25 +/- 3%) in jejunal blood flow, whereas neurotensin release
reached a maximum (1.14 +/- 0.34 pmol X min-1 X 100 g-1) 2 min after
initiation of the response and then returned to control. Venous neurotensin
concentrations also reached a maximum (51 +/- 17 pmol/l) at 2 min. There
were no significant changes in either blood flow or neurotensin release in
response to the other test solutions. Intra-arterial infusion of
neurotensin did not significantly decrease jejunal vascular resistance (-12
+/- 3%) until venous concentrations of 478 +/- 101 pmol/l were attained. It
seems unlikely, then, that neurotensin plays any role in the regulation of
the lipid-induced jejunal hyperemia.
