AJP - Gastrointestinal and Liver Physiology, Vol 251, Issue 6 752-G758, Copyright © 1986 by American Physiological Society
Effect of selective proximal vagotomy without and with pyloroplasty on gastroduodenal motility
G. E. Holle, S. B. Reiser and K. W. Frey
The effect of selective proximal vagotomy (SPV) was examined in six dogs on
the gastric emptying of solid food and the motility of the antrum and
duodenum (basic rhythm, motility index, and contractile activity
percentage). Emptying and motility were also examined in three dogs after
additional submucosal pyloroplasty (SMP). Electrical and motor activities
were tested in fasted and fed states. The meal consisted of 300 g of
standard protein-mixed meal. Determination of gastric emptying by X ray
were conducted with the same meal mixed with barium sulfate. All animals
showed delayed emptying of solid food after SPV. Antral motility increased
nonsignificantly in the digestive state, whereas duodenal motility
decreased, resulting in an increased antroduodenal motor gradient. In the
interdigestive state the motility of the antrum decreased significantly.
Additional SMP normalized the emptying delay, but decreased digestive and
interdigestive motility below the normal values. In conclusion, the
emptying delay after SPV is caused at least in part by the altered
functional condition of the immediate pyloric region.
