AJP - Gastrointestinal and Liver Physiology, Vol 252, Issue 1 40-G44, Copyright © 1987 by American Physiological Society
Gastrin is not a physiological regulator of pancreatic exocrine secretion in the dog
E. Kohler, C. Beglinger, V. Eysselein, U. Grotzinger and K. Gyr
The role of gastrin as a regulator of exocrine pancreatic secretion has not
been proven adequately. In the present study we therefore compared the
relative molar potencies of sulfated and unsulfated gastrin 17 with
structurally related CCK peptides (synthetic CCK-8 and natural porcine
CCK-33) in stimulating exocrine pancreatic secretion in conscious dogs.
Dose response curves were constructed for pancreatic and gastric acid
secretion. Plasma gastrin levels after exogenous gastrin 17-I and -II were
compared with postprandial gastrin concentrations (meal: ground beef 20
g/kg body wt). The molar potency estimates calculated with synthetic CCK8
as standard (potency = 1.00) for pancreatic protein secretion were natural
porcine 50% pure CCK-33 1.60, gastrin 17-I 0.12, and gastrin 17-II 0.16.
All four peptides induced a dose-dependent increase in pancreatic
bicarbonate output. However, the blood concentrations needed to stimulate
pancreatic secretion were above the postprandial gastrin levels. Our data
indicate that both gastrin 17 peptides are not physiological regulators of
pancreatic enzyme secretion in dogs.
