AJP - Gastrointestinal and Liver Physiology, Vol 252, Issue 2 262-G271, Copyright © 1987 by American Physiological Society
A high linoleic acid diet diminishes enhanced intestinal uptake of sugars in diabetic rats
A. B. Thomson, M. Keelan, M. T. Clandinin and K. Walker
Intestinal absorption is altered in rats by diabetes and by dietary
manipulation. For 5 wk rats were fed chow (C) or semisynthetic diets
containing isocaloric amounts of a high content of either polyunsaturated
(P) or saturated (S) fatty acids; then half were rendered hyperglycemic
with streptozotocin while the remaining half served as nondiabetic
controls. Studies were performed after a total of 8 wk on C, P, or S.
Jejunal villous surface area was greater in diabetic rats than in control
rats fed C or S, whereas the jejunal mucosal surface area was significantly
greater in diabetic animals than in control animals only when they were fed
S. Ileal mucosal surface area was similar in diabetic and in control rats
fed C, S, or P; although ileal villous surface area was greater in diabetic
than in control rats only when they were fed C. The jejunal and ileal
uptake of varying concentrations of glucose and galactose was higher in
diabetic rats than controls fed C or S. In contrast, the enhanced uptake of
these sugars was reduced or normalized in diabetic rats fed P. The jejunal
brush-border membrane (BBM) content of phospholipids was higher in diabetic
than in control rats fed chow, but there was no difference in diabetic vs.
control animals fed P or S in BBM total free fatty acids, phospholipids, or
cholesterol. Thus feeding a high linoleic acid diet diminishes the enhanced
intestinal uptake of glucose and galactose in diabetic rats.(ABSTRACT
TRUNCATED AT 250 WORDS)
