AJP - Gastrointestinal and Liver Physiology, Vol 252, Issue 4 529-G534, Copyright © 1987 by American Physiological Society

ARTICLES

Development of cholecystokinin binding sites in rat upper gastrointestinal tract

P. H. Robinson, T. H. Moran, M. Goldrich and P. R. McHugh

Autoradiography using 125I-labeled Bolton Hunter-CCK-33 was used to study the distribution of cholecystokinin binding sites at different stages of development in the rat upper gastrointestinal tract. Cholecystokinin (CCK) binding was present in the distal stomach, esophagus, and gastroduodenal junction in the rat fetus of gestational age of 17 days. In the 20-day fetus, specific binding was found in the gastric mucosa, antral circular muscle, and pyloric sphincter. Mucosal binding declined during postnatal development and had disappeared by day 15. Antral binding declined sharply between day 10 and day 15 and disappeared by day 50. Pyloric muscle binding was present in fetal stomach and persisted in the adult. Pancreatic CCK binding was not observed before day 10. These results suggest that CCK may have a role in the control of gastric emptying and ingestive behavior in the neonatal rat.

This article has been cited by other articles:

				C.-S. Yuan, A. S. Attele, L. Dey, and J.-T. Xie Gastric Effects of Cholecystokinin and Its Interaction with Leptin on Brainstem Neuronal Activity in Neonatal Rats J. Pharmacol. Exp. Ther., October 1, 2000; 295(1): 177 - 182. [Abstract] [Full Text]

				C.-S. Yuan, D. Liu, and A. S. Attele GABAergic Effects on Nucleus Tractus Solitarius Neurons Receiving Gastric Vagal Inputs J. Pharmacol. Exp. Ther., August 1, 1998; 286(2): 736 - 741. [Abstract] [Full Text]