AJP - Gastrointestinal and Liver Physiology, Vol 252, Issue 4 568-G573, Copyright © 1987 by American Physiological Society
Luminal and plasma glucose concentrations on intestinal fluid absorption and lymph flow
J. S. Lee
The effect of luminal (GL) and plasma (GP) glucose concentration on
intestinal fluid absorption and lymph flow in the rat was studied. When GL
was zero, fluid absorption rate (JV), total lymph flow, and "excess lymph
flow" (JLe) during absorption from Krebs-Ringer solution was 155 +/- 16, 30
+/- 4, and 11 +/- 4 microliters X cm-1 X h-1, respectively, and JLe
accounted for 7% of JV. JLe was the difference between total lymph flow and
basal (nonabsorptive) lymph flow (JLb). In the presence of 28 mM glucose,
JV and JLe increased by 37% to 212 +/- 22 and by 318% to 46 +/- 6
microliter X cm-1 X h-1, respectively. There was no further increase of
either parameter when GL was 56 or 100 mM. When GL was zero and GP was
increased to 43-64 mM during intravenous infusion of hypertonic glucose
solution (2.78 M), JV and JLe increased by 32-35 and 313-380%,
respectively, compared with that when GP was normal (11-14 mM). When GL was
28 mM and GP was 56 mM, a maximal rate of JV and JLe was obtained, and JLe
accounted for 43 +/- 7% of JV. During infusion of hypertonic NaCl solution
(1.54 M), JV decreased with little change in JLe. Furthermore, during
infusion of either NaCl or glucose solution, the increase of plasma
osmolarity resulted in approximately 100% increase of JLb. The results
demonstrate that either GL, or GP, or both, increased JV and especially
increased JLe.(ABSTRACT TRUNCATED AT 250 WORDS)
