AJP - Gastrointestinal and Liver Physiology, Vol 252, Issue 5 692-G698, Copyright © 1987 by American Physiological Society
Splanchnic blood flow during stimulation of gastrointestinal growth
M. G. Ulrich-Baker, W. R. Smidt, T. S. Gaginella and D. N. Granger
The primary objective of this study is to determine whether a relationship
exists between the rate of blood flow and the gastrointestinal response to
a trophic stimulus. A new prostaglandin E2 (PGE2) derivative, Ro 22-1327,
was employed as a growth stimulus. Rats were treated by gavage for 14 days
with Ro 22-1327 (0.5 and 5 mg/kg). The vascular and trophic effects of Ro
22-1327 were studied in the gastric antrum and oxyntic gland area,
duodenum, jejunum, ileum, colon, liver, and pancreas. Generally, the
trophic effects were 1) similar to those reported with other PGE2
analogues, 2) more pronounced in the antrum than in the oxyntic gland area,
3) greatest in the stomach, diminishing toward the colon, and 4) dose
dependent. Organ blood flows were largely unaffected by the low-dose
treatment, while the high-dose treatment tended to increase blood flow. The
changes in blood flow were most pronounced proximally where the trophic
responses were maximal. We speculate that the greater trophic response to
the high dose of Ro 22-1327 may reduce the vasoconstriction produced by
this agent.
