AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 252: G825-G831, 1987;
0193-1857/87 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hoadley, J. E.
Right arrow Articles by Cousins, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hoadley, J. E.
Right arrow Articles by Cousins, R. J.

AJP - Gastrointestinal and Liver Physiology, Vol 252, Issue 6 825-G831, Copyright © 1987 by American Physiological Society

ARTICLES

Kinetic analysis of zinc uptake and serosal transfer by vascularly perfused rat intestine

J. E. Hoadley, A. S. Leinart and R. J. Cousins

Transport kinetics were examined for uptake of 65Zn from the lumen and for transport of mucosal 65Zn subsequent to uptake in the isolated, vascularly perfused intestines of rats fed either a zinc-deficient or zinc-adequate diet. Zinc depletion influenced the intestinal transport of zinc by stimulating a saturable uptake mechanism, reducing secretion of mucosal 65Zn into the lumen, and increasing the rate of 65Zn turnover in a rapidly absorbed mucosal zinc compartment. Uptake of 65Zn involved both saturable and nonsaturable processes. The saturable process was stimulated by zinc depletion with the apparent maximal transport rate for the saturable mechanism increasing from 60 to 180 nmol Zn X g-1 X 30 min-1. Most of the 65Zn taken up was not involved in the short-term secretion or absorption, and mucosal 65Zn retention was independent of dietary zinc status. Absorption of mucosal 65Zn was nonsaturable, involved a rapid exchanging zinc compartment, and was stimulated by zinc depletion. The half-life for 65Zn in this mucosal zinc compartment was approximately 24 min in the zinc-adequate group and 13 min in the zinc-depleted group.


This article has been cited by other articles:


Home page
 J. Exp. Biol.Home page
C. N. Glover and C. Hogstrand
In vivo characterisation of intestinal zinc uptake in freshwater rainbow trout
J. Exp. Biol., January 1, 2002; 205(1): 141 - 150.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
P. Coyle, J. C. Philcox, and A. M. Rofe
Metallothionein-Null Mice Absorb Less Zn from an Egg-White Diet, but a Similar Amount from Solutions, although with Altered Intertissue Zn Distribution
J. Nutr., February 1, 1999; 129(2): 372 - 379.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. R. Davis, R. J. McMahon, and R. J. Cousins
Metallothionein Knockout and Transgenic Mice Exhibit Altered Intestinal Processing of Zinc with Uniform Zinc-Dependent Zinc Transporter-1 Expression
J. Nutr., May 1, 1998; 128(5): 825 - 831.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. J. McMahon and R. J. Cousins
Regulation of the zinc transporter ZnT-1 by dietary zinc
PNAS, April 28, 1998; 95(9): 4841 - 4846.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online