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Am J Physiol Gastrointest Liver Physiol 253: G134-G138, 1987;
0193-1857/87 $5.00
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AJP - Gastrointestinal and Liver Physiology, Vol 253, Issue 2 134-G138, Copyright © 1987 by American Physiological Society

ARTICLES

Kinetics of transepithelial movement of heavy metals in rat jejunum

E. C. Foulkes and D. M. McMullen

The kinetics of the transepithelial movement of heavy metals were studied in the perfused rat jejunum in situ. The peak appearance time (TET) of Zn, Ni, and Cd in portal venous blood was determined after their transient (10 s) introduction into the intestinal lumen. Observed TET values for these metals were positively correlated with their affinities for metallothionein and agreed with those predicted on the basis of a linear three-compartment model that does not allow for paracellular pathways. Further evidence was provided to support the hypothesis that Cd absorption consists first of Cd binding to negative membrane charges followed by a temperature-dependent internalization step.


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E. C. Foulkes
Transport of Toxic Heavy Metals Across Cell Membranes
Experimental Biology and Medicine, March 1, 2000; 223(3): 234 - 240.
[Abstract] [Full Text]


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